Alcohol Recovery: Acamprosate vs Naltrexone?

What Is Acamprosate?

Acamprosate (brand name Campral) is a medication used to help people with alcohol use disorder. It helps maintain abstinence after they stop drinking. It does not directly help someone stop drinking. Instead, it supports long-term sobriety.

Heavy drinking disrupts a person’s brain chemistry. Acamprosate restores chemical balance in the brain after alcohol cessation. In 2004, acamprosate received its FDA approval.

How It Works

The effects of alcohol abuse target neurotransmitters in the brain, especially GABA and glutamate. Once a person stops drinking, these changes can lead to symptoms of anxiety, restlessness, and insomnia. Acamprosate works to normalize this imbalance. It helps the brain function more calmly without alcohol.

Who It’s For

Acamprosate is usually prescribed for people who have already controlled alcohol dependence and want to stay sober. It’s best for those committed to abstinence.

Dosage and Use

It comes in the form of oral tablets (333 mg per tablet). The typical regimen is two tablets, three times daily at the exact time. This schedule can be a challenge for some people. Adhering to this regimen is important for the medication to be effective

Side Effects

Common side effects include:

• Diarrhea
• Nausea
• Loss of appetite
• Fatigue
• Anxiety

Acamprosate is not processed through the liver. So, it is safer for people with liver disease. However, those with severe kidney impairment should avoid this medication.

What Is Naltrexone?

Naltrexone is another widely used medication in alcohol recovery. It works to reduce cravings and the rewarding effects of alcohol. Its oral form received FDA approval in 1994, and its extended injectable form (Vivitrol) in 2006.

How It Works

Naltrexone is an opioid antagonist that blocks certain receptors in the brain responsible for feelings of pleasure and reward. Alcohol, while taking naltrexone, reduces the euphoria. Alcohol is less rewarding and decreases the person’s desire to keep drinking.

Who It’s For

Naltrexone is ideal for people who are still struggling with cravings. It also reduces the craving for alcohol, even if they have not achieved full abstinence yet.

Dosage and Use

It comes in two forms. Oral tablets (50 mg daily); and the extended-release injection administered (380 mg intramuscular injection) once a month. The injection can be especially  helpful for those who have trouble taking pills daily.

Side Effects

Common side effects may include:

• Nausea
• Headache
• Dizziness
• Fatigue
• Anxiety
• Liver function concerns (requires monitoring)

Individuals dependent on opioids should not use Naltrexone. It can trigger sudden withdrawal.

Acamprosate vs Naltrexone- What’s the Difference

Understanding the major differences between these medications is crucial when deciding which may work better for you or a loved one.

The target symptoms of the use of acamprosate include:

• Emotional distress during abstinence, insomnia, restlessness)
• Craving due to neurochemical imbalance

The target symptoms for the use of naltrexone include

• Cravings triggered by alcohol cues or memories
• Reward-seeking behavior after drinking
• Desire to continue drinking once alcohol is consumed (binge prevention)

Naltrexone vs acamprosate for alcohol is effective. Acamprosate targets post-acute withdrawal symptoms and helps maintain emotional stability after quitting. Naltrexone focuses on reducing cravings and the “reward” feeling associated with drinking. It makes it effective in early or relapse-prone recovery stages.

In summary, acamprosate is preventive while naltrexone is responsive.

Which One Is Right for You?

Both acamprosate and naltrexone have helped thousands of people recover from alcohol addiction. But they are not interchangeable. The decision between acamprosate and naltrexone depends on several personal factors. Here’s what to consider:

Your Stage in Recovery

• Suppose you have already quit drinking and want help staying sober. Acamprosate may be more appropriate.
• If you are still struggling with cravings or relapse triggers. Naltrexone may help reduce urges and drinking frequency.

Acamprosate vs naltrexone length of abstinence is also different. So is the cost of acamprosate sale for alcohol.

When to use Acamprosate vs Naltrexone

• Choose acamprosate if you’re aiming for complete abstinence and want to stabilize your brain chemistry.
• Choose naltrexone if you are still drinking, trying to reduce drinking and cravings, or prevent relapse during early recovery.

Your Medical History

• Do you have liver disease? Acamprosate is safer.
• Do you have kidney problems? Naltrexone is safer.
• Are you currently using opioids? Avoid naltrexone.

Medication Preference

• Can you remember to take medication 3 times a day? Acamprosate could work.
• Prefer once-daily dosing or monthly shots? Naltrexone may be better.

Ultimately, the decision should be made with a doctor experienced in addiction medicine.

Combining Medication with Therapy and Support

No medication is a magic bullet. Combining behavioral therapy, counseling support groups, and outpatient or residential rehab programs with medication significantly improves recovery outcomes.

The best treatment for AUD is the one that matches your goals, your biology, and your readiness to change. Talking to a therapist is the best first step to determine what will work for you.

Ready to Take Control of Your Recovery Journey?

Struggling with alcohol doesn’t define you! Your courage to seek help does. Taking the first step toward recovery from alcohol addiction is a bold and life-changing decision. If you’re ready to regain control, heal your body and mind, and rebuild your life, you’re not alone—and help is available.

Alcohol Use Disorder (AUD) affects millions of individuals and families. It often leads to strained relationships, health issues, and emotional distress. But no matter how deep a person is into alcohol, recovery is always possible. The key is finding the right support system and treatment approach that fits your needs.

Our compassionate team at the Hope House is here to guide you every step of the way. Call now and reclaim your life. Your recovery journey is personal, and you deserve the best support available.

At its core, recovery is not just about stopping alcohol use. It is about rediscovering your purpose, restoring your health, and learning to live life without depending on alcohol. It is about gaining the tools and confidence to thrive.

You deserve a life free from the grip of addiction. And it all begins with one powerful choice: to seek help. Your path to recovery is within reach. Take the first step now.