SSRI Withdrawal: Effects and Symptoms of SSRI Withdrawal

Medical Providers:
Dr. Michael Vines, MD
Alex Spritzer, FNP, CARN-AP, PMHNP
Clinical Providers:
Natalie Foster, LPC-S, MS
Last Updated: November 27, 2023

Managing SSRI withdrawal can be a difficult experience for those who have relied on selective serotonin reuptake inhibitors (SSRIs) to maintain their mental well-being.

This guide delves into the common symptoms and side effects that may occur during SSRI discontinuation, providing helpful information on what to expect throughout the process. With this knowledge, individuals can approach the transition with greater awareness and take proactive steps to find the support they need.

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What is SSRI Withdrawal?

SSRI withdrawal describes the range of symptoms and effects that can arise when a person stops taking selective serotonin reuptake inhibitors, a common type of antidepressant. These symptoms may include mood changes, dizziness, and other physical or emotional shifts as the brain readjusts to functioning without the medication.

Recognizing how this process works is essential for anyone tapering off SSRIs, as it enables them to anticipate potential challenges and better manage the transition.

What Are the Symptoms of SSRI Withdrawal?

When stopping SSRI medications, individuals may encounter a variety of withdrawal symptoms as their bodies adapt to the medication’s absence. The nature and severity of these effects can differ from person to person. Below are some of the most common symptoms associated with SSRI withdrawal:

photo depicting a sad person

When individuals discontinue antidepressant use, they may experience sudden mood fluctuations. Feelings of irritability, sadness, or anxiety can become more pronounced, potentially interfering with their everyday activities and overall well-being.

photo of a man sitting and having a hard time because of dizziness

Discontinuing SSRIs may cause sensations of dizziness or feeling off-balance, as if the world is spinning. This can affect coordination and make routine tasks more challenging to manage.

During antidepressant withdrawal, some individuals may experience gastrointestinal issues such as nausea or vomiting, which can be quite uncomfortable and distressing.

photo of woman experiencing headache

Many individuals who stop taking SSRIs experience headaches that resemble tension headaches or migraines. These can be quite painful and may interfere with daily activities.

A common effect of discontinuing SSRIs is intense fatigue and low energy levels. This can make it difficult to complete daily tasks and maintain motivation.

photo of a woman sitting on the floor having flu like symptoms

During SSRI withdrawal, it’s common to experience flu-like symptoms such as muscle aches, sweating, chills, and overall discomfort. These sensations can be physically draining and mentally challenging to cope with.

Photo Depicting Insomnia Which Is A Xanax Withdrawal Symptom

Sleep disturbances are common when discontinuing SSRIs. Individuals may have difficulty falling asleep or experience intense, vivid dreams that disrupt rest, making it challenging to get quality sleep.

photo of a man showing distress and agitation

Discontinuing SSRIs can lead to difficulties with concentration, memory, and clear thinking. It often feels like a mental fog that makes focusing on everyday tasks more challenging.

photo of woman suffering from a stomach pain

During SSRI withdrawal, some people experience digestive issues such as diarrhea, constipation, or stomach cramps. These symptoms can add to the overall physical discomfort that often accompanies the discontinuation process.

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The timeline for SSRI withdrawal can differ greatly between individuals, as each person’s experience is unique. Still, the following outline offers a general overview to help illustrate what the process may look like:

Early Symptoms (1-3 Days)

Within the first few days of stopping antidepressants, you may begin to notice mild symptoms such as dizziness and mood fluctuations, signaling the start of your body’s adjustment period.

Peak Symptoms (1-2 Weeks)

By the end of the first week, withdrawal symptoms often reach their peak. You may experience stronger mood swings, headaches, and heightened physical or emotional discomfort during this period.

Tapering Off (2-6 Weeks)

As the weeks progress, withdrawal symptoms typically start to ease, though some lingering effects may persist and continue to cause mild discomfort.

Residual Symptoms (Several Weeks to Months)

For some individuals, mild withdrawal symptoms can persist for several weeks or even months, gradually becoming less frequent and less intense over time.

Full Recovery (Months to a Year)

Most people ultimately make a full recovery and stop experiencing withdrawal symptoms, though the duration of this process can differ greatly from one individual to another.

How Long Does SSRI Withdrawal Last?

The duration of SSRI withdrawal differs from person to person, with most individuals experiencing symptoms for a few weeks to several months. Some may have lingering but mild effects that last longer, while others recover more rapidly.

It’s important to consult a healthcare professional for personalized guidance and support to ensure a safe and manageable withdrawal process.

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What is SSRI Detox?

Stopping SSRIs typically requires gradually lowering the dosage under a doctor’s supervision. This careful tapering helps reduce potential emotional and physical withdrawal symptoms, allowing the body to adjust safely and more comfortably.

SSRI Withdrawal Treatment

Treatment for SSRI withdrawal centers on managing the symptoms that may occur when stopping antidepressant use. Doctors often recommend a gradual tapering plan, prescribe medications to ease specific symptoms, suggest therapy, and promote healthy lifestyle changes to support the withdrawal process.

This well-rounded approach helps reduce discomfort and promotes a smoother, more successful transition off SSRIs.

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