Medical Providers:
Dr. Michael Vines, MD
Alex Spritzer, FNP, CARN-AP, PMHNP
Clinical Providers:
Natalie Foster, LPC-S, MS
Last Updated: September 25, 2025
Recent data shows fentanyl is now one of the leading drivers of the opioid crisis, linked to over 70,000 overdose deaths in 2021. Because this drug is so addictive, safely managing fentanyl withdrawal and detox is essential for lasting recovery. In this article, we’ll break down what to expect during fentanyl withdrawal—from symptoms and timelines to why a professional detox program can make all the difference.
Fentanyl is a powerful opioid that attaches to the brain’s opioid receptors, triggering strong physical and emotional effects. When someone stops using it, the brain and body must adjust to its absence—this sudden shift is what causes fentanyl withdrawal symptoms to appear.
Fentanyl withdrawal, like withdrawal from other opioids, can bring on a range of difficult symptoms—both physical and emotional. Some of the most common include:
These symptoms can make the process feel overwhelming, which is why having the right support during detox is so important.
Fentanyl withdrawal usually isn’t life-threatening on its own, but it can be intensely uncomfortable and sometimes risky. Going through the process under medical supervision helps keep you safe and reduces the chance of complications. It’s also important to know that after detox, your body’s tolerance drops—making the risk of overdose higher if you relapse.
The timeline for fentanyl withdrawal looks different for everyone. Factors like how long someone has been using fentanyl, their dosage, and their level of dependence all play a role. Still, most people experience withdrawal in a few key stages:
In the early stage—usually within 12 to 48 hours after the last dose—flu-like symptoms often begin. Muscle aches, sweating, and restlessness are common during this time.
The peak stage typically hits between 48 and 72 hours and is often the toughest part of fentanyl withdrawal. Cravings can feel overwhelming, and symptoms like stomach upset, insomnia, and mood swings may be at their worst.
As withdrawal moves into the later stage, symptoms slowly start to ease. However, some people may still deal with lingering issues like mood changes, anxiety, or trouble sleeping for a while longer.
For some people, withdrawal doesn’t end right away. They may experience what’s known as post-acute withdrawal, where symptoms like anxiety, fatigue, mood swings, and even cravings can linger for weeks—or sometimes months.
How long fentanyl withdrawal lasts can differ from person to person. Factors like overall health, how long someone has been using, and the amount they’ve taken all play a role. Typically, the most intense symptoms peak within the first few days and begin to ease after a week or two. Still, some people may have lingering effects that last for several weeks—or even months.
The duration of fentanyl detox can vary depending on the individual’s specific circumstances. Typically, detoxification from fentanyl can last anywhere from a few days to a couple of weeks. However, it is important to note that detox alone is not sufficient for long-term recovery. It should be followed by comprehensive addiction treatment to address the underlying factors contributing to addiction and promote lasting recovery.
The length of fentanyl detox depends on each person’s situation. For some, it may last just a few days, while for others, it can take a couple of weeks. But detox is only the first step and is not sufficient. To build a strong foundation for long-term recovery, it’s important to follow detox with a full treatment program that addresses the root causes of addiction and supports lasting change.
If you or someone you love is struggling with fentanyl addiction, help is within reach. Arizona IOP offers compassionate outpatient treatment designed to fit your life while providing the care you need. Our programs combine evidence-based therapies, holistic approaches, and family support to guide you toward lasting recovery. Reach out to Arizona IOP today and take the first step toward healing and a brighter future.
